Basic Mass Spectrometry: Instrumentation

Mass spectrometry is an extremely useful tool in various fields: chemistry, molecular biology, medicine, environmental sciences, forensics, etc. It provides detailed information about the chemical composition of the sample. This course provides basic principles in Instrumentation and analysis methods in mass spectrometry - the way how you ionize the sample and transferring it to the gas phase, how to manipulate ions in the gas phase with electromagnetic field, and how to detect masses of the ions.

Lecture 1: Introduction

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Introduction to the basic course on mass spectrometry.
Handout (pdf, 901 kB)

Lecture 2: Ionization Methods

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This lesson gives an introduction to electron ionization, chemical ionization, electrospray ionization and MALDI.
Handout (pdf, 1,2 MB)

Lecture 3: Mass Analyzers - Part 1

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This lesson gives an introduction about mass analysis in magnetic and electrostatic sectors, in time-of-flight analysers, in quadrupoles, and in quadrupole ion traps.
Handout (pdf, 1,6 MB)

Lecture 4: Mass Analyzers - Part 2

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This lesson is about high resolution mass spectrometry with orbitrap- and ICR analysers.
Handout (pdf, 580 kB)

Lecture 5: Detectors

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This lesson shows working principles for the detection of ions.
Handout (pdf, 376 kB)

Mass Spectrometry Instrumentation

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Lectures on Mass Spectrometry Instrumentation